Damage-Associated Molecular Patterns in Inflammatory Diseases
Immune Network
;
: e27-2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-716244
ABSTRACT
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoartritis
/
Enfermedad de Parkinson
/
Artritis Reumatoide
/
Biomarcadores
/
Proteínas S100
/
Aterosclerosis
/
Receptores de Reconocimiento de Patrones
/
Enfermedad de Alzheimer
/
Proteínas de Choque Térmico
/
Sistema Inmunológico
Idioma:
Inglés
Revista:
Immune Network
Año:
2018
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS