Functional Characterization of the Major Outer Membrane Protein ( MspTL ) of Treponema lecithinolyticum
Journal of Bacteriology and Virology
;
: 47-54, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-71647
ABSTRACT
Treponema lecithinolyticum is known to be associated with rapidly progressive periodontitis. The full-length gene encoding the major surface protein MspTL of this organism was cloned and expressed by using the expression vector pQE30. Recombinant Msp TL (rMsp TL) protein was purified and functionally characterized. Msp TL was one of several T. lecithinolyticum surface proteins that bound to cultured human gingival fibroblasts (HGFs). As well, it strongly induced IL-6 production by HGFs. These observations suggest that MspTL contributes to pathogenesis of periodontitis by adhesion to host cells and by induction of the proinflammatory cytokine IL-6.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Periodontitis
/
Treponema
/
Interleucina-6
/
Células Clonales
/
Fibroblastos
/
Proteínas de la Membrana
/
Membranas
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of Bacteriology and Virology
Año:
2002
Tipo del documento:
Artículo
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