Diverse Ischemic Postconditioning Protocols Affect the Infarction Size in Focal Ischemic Stroke
Journal of Cerebrovascular and Endovascular Neurosurgery
;
: 159-167, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-717045
ABSTRACT
OBJECTIVE:
Ischemic postconditioning (IPostC), consisted of transient brain ischemia/reperfusion cycles, is considered to have neuroprotective effect. However, there is no best single protocol of IPostC, because varied factors like species tested and characteristics of the tissue may affect the efficacy of IPostC. Thus, we investgated whether different protocols of IPostC affect neuroprotective effects in experimental animal models. MATERIALS ANDMETHODS:
Through occlusion of middle cerebral artery (MCA) with intraluminal suture, stroke was induced in a transient focal ischemia model in mice. We conducted IPostC via brief and repeated MCA occlusion, 2 minutes after reperfusion, followed by different ischemia and reperfusion protocols. After procedure, functional neurological score and histological examination were evaluated.RESULTS:
IPostC with different protocols resulted in diverse effects. Among them, a protocol that consists of 3 cycle of IPostC significantly reduced the infarction size 3 days after stroke.CONCLUSION:
IPostC was confirmed to reduce infarction size. The effects of IPostC are definitely affected by differences in the protocol used, including the number of cycles, the duration of individual ischemia/reperfusion episode and the entire duration of the IPostC stimuli.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Suturas
/
Encéfalo
/
Reperfusión
/
Fármacos Neuroprotectores
/
Arteria Cerebral Media
/
Accidente Cerebrovascular
/
Modelos Animales
/
Poscondicionamiento Isquémico
/
Infarto
/
Isquemia
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Cerebrovascular and Endovascular Neurosurgery
Año:
2018
Tipo del documento:
Artículo
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