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A Case of Wernicke's Encephalopathy Following Fluorouracil-based Chemotherapy
Journal of Korean Medical Science ; : 747-750, 2009.
Artículo en Inglés | WPRIM | ID: wpr-71709
ABSTRACT
The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its effects on the bone marrow and gastrointestinal epithelium. Neurotoxicity caused by 5-FU is uncommon, although acute and delayed forms have been reported. Wernicke's encephalopathy is an acute, neuropsychiatric syndrome resulting from thiamine deficiency, and has significant morbidity and mortality. Central nervous system neurotoxicity such as Wernicke's encephalopathy following chemotherapy with 5-FU has been reported rarely, although it has been suggested that 5-FU can produce adverse neurological effects by causing thiamine deficiency. We report a patient with Wernicke's encephalopathy, reversible with thiamine therapy, associated with 5-FU-based chemotherapy.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tiamina / Deficiencia de Tiamina / Encefalopatía de Wernicke / Imagen por Resonancia Magnética / Neoplasias Nasofaríngeas / Enfermedad Aguda / Fluorouracilo / Antimetabolitos Antineoplásicos Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tiamina / Deficiencia de Tiamina / Encefalopatía de Wernicke / Imagen por Resonancia Magnética / Neoplasias Nasofaríngeas / Enfermedad Aguda / Fluorouracilo / Antimetabolitos Antineoplásicos Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2009 Tipo del documento: Artículo