Successful Salvage Unrelated Umbilical Cord Blood Transplantation with Two Units After Engraftment Failure with Single Unit in Severe Aplastic Anemia
Journal of Korean Medical Science
; : 744-746, 2009.
Article
en En
| WPRIM
| ID: wpr-71710
Biblioteca responsable:
WPRO
ABSTRACT
Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Twounit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Hibridación Fluorescente in Situ
/
Trasplante de Células Madre de Sangre del Cordón Umbilical
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Enfermedad Injerto contra Huésped
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Histocompatibilidad
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Antígenos HLA
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Anemia Aplásica
Límite:
Child, preschool
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Female
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Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2009
Tipo del documento:
Article