Lupus Anticoagulant-hypoprothrombinemia Syndrome that did not Progress to Systemic Lupus Erythematosus: A Case Report / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 155-160, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-71728
ABSTRACT
Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare disorder, and appears mostly in children. The primary concern is its potential development into systemic lupus erythematosus (SLE). A 5-year-old patient was hospitalized with multiple purpuric lesions. A markedly prolonged prothrombin time and activated partial thromboplastin time were observed and were not corrected after mixing with normal plasma. Decreased factor II activity was consistent with LA-HPS. Identifying risk factors that play an important role in the development of SLE in patients with LA-HPS is of importance. Based on the case described here, anti-double stranded (ds) DNA antibody and the Sapporo criteria for antiphospholipid syndrome are related to subsequent SLE development, whereas there is no correlation with the results of the lupus anticoagulant (LA) test. We recommend an early and serial examination of anti-ds DNA antibody and full evaluation of Sapporo criteria for the screening of patients with LA-HPS who may progress to SLE.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tiempo de Tromboplastina Parcial
/
Plasma
/
Tiempo de Protrombina
/
ADN
/
Protrombina
/
Tamizaje Masivo
/
Factores de Riesgo
/
Inhibidor de Coagulación del Lupus
/
Síndrome Antifosfolípido
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Niño
/
Child, preschool
/
Humanos
Idioma:
Inglés
Revista:
Clinical Pediatric Hematology-Oncology
Año:
2015
Tipo del documento:
Artículo
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