HBsAg-Negative, Anti-HBc–Negative Patients Still Have a Risk of Hepatitis B Virus–Related Hepatitis after Autologous Stem Cell Transplantation for Multiple Myeloma or Malignant Lymphoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 1121-1129, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-717453
ABSTRACT
PURPOSE:
Although hepatitis B surface antigen (HBsAg)–negative, hepatitis B core antibody (anti-HBc)–negative patients are not considered to be at risk for hepatitis B virus (HBV)–related hepatitis, the actual risk remains to be elucidated. This study aimed to evaluate the risk of HBV-related hepatitis in HBsAg-negative, anti-HBc–negative patients receiving autologous stem cell transplantation (ASCT) for multiple myeloma (MM) or malignant lymphoma. MATERIALS ANDMETHODS:
We retrospectively reviewed data from 271 HBsAg-negative patients (161 anti-HBc–negative and 110 anti-HBc–positive at the time of ASCT) who received ASCT for MM or lymphoma. The risk of HBV-related hepatitis was analyzed according to the presence of anti-HBc. HBV serology results at the time of ASCT were compared with those at the time of diagnosis of MM or lymphoma.RESULTS:
Three patients (two anti-HBc–negative MMs and one anti-HBc–positive MM) developed HBV-related hepatitis after ASCT. The rate of HBV-related hepatitis did not differ among patients with or without anti-HBc status (p=0.843). HBV-related hepatitis more frequently occurred in MM patients than in lymphoma patients (p=0.041). Overall, 9.1% of patients (16.7% with MM and 5.4% with lymphoma) who were HBsAg–negative and anti-HBc–positive at the time of diagnosis had lost anti-HBc positivity during chemotherapy prior to ASCT.CONCLUSION:
Our data suggest that HBsAg-negative, anti-HBc–negative patients at the time of ASCT for MM or lymphoma still might be at a risk for HBV-related hepatitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Madre
/
Virus de la Hepatitis B
/
Estudios Retrospectivos
/
Trasplante de Células Madre
/
Diagnóstico
/
Quimioterapia
/
Hepatitis
/
Hepatitis B
/
Antígenos de Superficie de la Hepatitis B
/
Linfoma
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2018
Tipo del documento:
Artículo
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