Effective Delivery of Exogenous Compounds to the Optic Nerve by Intravitreal Injection of Liposome
Korean Journal of Ophthalmology
;
: 417-423, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-717485
ABSTRACT
PURPOSE:
To improve the treatment efficiency of optic nerve diseases by delivering therapeutic materials to the optic nerve directly.METHODS:
We tried to optimize liposomal composition to deliver a payload to the optic nerve efficiently when it is injected intravitreally. After loading dexamethasone into this liposome, we tested the therapeutic effect of liposomes in this treatment using a murine model of ischemic optic neuropathy.RESULTS:
Our optimized liposome can deliver its payload to the optic nerve more efficiently than other tested compositions. Moreover, dexamethasone-loaded liposomes had a significant therapeutic effect in a murine model of ischemic optic neuropathy.CONCLUSIONS:
Here, we demonstrate the optimal composition of liposomes that could efficiently deliver intravitreally injected exogenous compounds to the optic nerve. We expect that the intravitreal injection of liposomes with the suggested composition would improve the delivery efficacy of therapeutic compounds to the optic nerve.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Nervio Óptico
/
Dexametasona
/
Enfermedades del Nervio Óptico
/
Neuropatía Óptica Isquémica
/
Inyecciones Intravítreas
/
Liposomas
Idioma:
Inglés
Revista:
Korean Journal of Ophthalmology
Año:
2018
Tipo del documento:
Artículo
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