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Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling
Psychiatry Investigation ; : 1000-1006, 2018.
Artículo en Inglés | WPRIM | ID: wpr-717817
ABSTRACT

OBJECTIVE:

Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion.

METHODS:

Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY).

RESULTS:

5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors.

CONCLUSION:

The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Control Social Formal / Aislamiento Social / Serotonina / 8-Hidroxi-2-(di-n-propilamino)tetralin / Corteza Prefrontal / Receptor de Serotonina 5-HT1A / Depresión / Agonistas del Receptor de Serotonina 5-HT1 / Hipocampo Límite: Animales Idioma: Inglés Revista: Psychiatry Investigation Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Control Social Formal / Aislamiento Social / Serotonina / 8-Hidroxi-2-(di-n-propilamino)tetralin / Corteza Prefrontal / Receptor de Serotonina 5-HT1A / Depresión / Agonistas del Receptor de Serotonina 5-HT1 / Hipocampo Límite: Animales Idioma: Inglés Revista: Psychiatry Investigation Año: 2018 Tipo del documento: Artículo