Clozapine-related Sudden Pericarditis in a Patient Taking Long Acting Aripiprazole and Valproate: A Case Report
Clinical Psychopharmacology and Neuroscience
;
: 505-507, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-718208
ABSTRACT
Clozapine may be associated with cardiovascular adverse effects including QTc prolongation and, more rarely, with myocarditis and pericarditis. Although rare, these latter cardiovascular adverse effects may be life-threatening and must be immediately recognized and treated. Several cases of clozapine related-pericarditis have been described and often it has a subtle and insidious onset with symptoms that may be often misdiagnosed with psychiatric manifestations (e.g. anxiety, panic or somatization) leading to a delayed correct diagnosis with potential fatal consequences. In the present report we describe the case of a 27-year-old girl with schizoaffective disorder taking long acting aripiprazole and valproate who developed a sudden onset clozapine-related pericarditis during titration phase that resolved with immediate clozapine discontinuation and indomethacin administration. We underline the importance of an early diagnosis of clozapine-related pericarditis and the need to have monitoring protocols to prevent this potentially fatal adverse effect especially when polypharmacy is administered to patients taking clozapine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ansiedad
/
Pánico
/
Pericarditis
/
Trastornos Psicóticos
/
Indometacina
/
Ácido Valproico
/
Monitoreo de Drogas
/
Clozapina
/
Polifarmacia
/
Diagnóstico Precoz
Tipo de estudio:
Estudio diagnóstico
/
Guía de Práctica Clínica
/
Estudio de tamizaje
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Clinical Psychopharmacology and Neuroscience
Año:
2018
Tipo del documento:
Artículo
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