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Antenatal Corticosteroids and Clinical Outcomes of Preterm Singleton Neonates with Intrauterine Growth Restriction
Neonatal Medicine ; : 161-169, 2018.
Artículo en Inglés | WPRIM | ID: wpr-718343
ABSTRACT

PURPOSE:

We assessed the influence of antenatal corticosteroid (ACS) on the inhospital outcomes of intrauterine growth restriction (IUGR) infants.

METHODS:

A retrospective study was conducted with singletons born at 23⁺⁰ to 33⁺⁶ weeks of gestation at Seoul National University Hospital from 2007 to 2014. We compared clinical outcomes between infants who received ACS 2 to 7 days before birth (complete ACS), at 7 days (incomplete ACS), and those who did not receive ACS in IUGR and AGA infants. Multivariate logistic regression using Firth's penalized likelihood was performed.

RESULTS:

304 neonates with 91 IUGR neonates were eligible. Among AGA neonates, mortality (adjusted odds ratio [aOR], 0.13; 95% confidence interval [CI], 0.02 to 0.78), hypotension within 7 postnatal days (aOR, 0.20; 95% CI, 0.06 to 0.64), and severe bronchopulmonary dysplasia (BPD) or death (aOR, 0.24; 95% CI, 0.07 to 0.77) were lower in complete ACS group after adjusting for pregnancy induced hypertension and uncontrolled preterm labor. Mortality (aOR, 0.18; 95% CI, 0.04 to 0.78), hypotension (aOR, 0.26; 95% CI, 0.09 to 0.70), and severe BPD or death (aOR, 0.33; 95% CI, 0.12 to 0.92) were also lower in the incomplete ACS group. Among IUGR infants, after adjusting for birth weight and 5-minute Apgar score, inhaled nitric oxide use within 14 postnatal days was lower in both complete ACS (aOR, 0.07; 95% CI, 0.01 to 0.67) and incomplete ACS (aOR, 0.04; 95% CI, 0.01 to 0.37) groups.

CONCLUSION:

ACS was not effective in reducing morbidities in IUGR preterm infants.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Puntaje de Apgar / Atención Prenatal / Esteroides / Peso al Nacer / Displasia Broncopulmonar / Recien Nacido Prematuro / Modelos Logísticos / Oportunidad Relativa / Estudios Retrospectivos / Mortalidad Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Lactante / Recién Nacido / Embarazo País/Región como asunto: Asia Idioma: Inglés Revista: Neonatal Medicine Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Puntaje de Apgar / Atención Prenatal / Esteroides / Peso al Nacer / Displasia Broncopulmonar / Recien Nacido Prematuro / Modelos Logísticos / Oportunidad Relativa / Estudios Retrospectivos / Mortalidad Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Lactante / Recién Nacido / Embarazo País/Región como asunto: Asia Idioma: Inglés Revista: Neonatal Medicine Año: 2018 Tipo del documento: Artículo