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ABSTRACT

PURPOSE:

Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerative disease and to broaden understanding thereof. MATERIALS AND

METHODS:

We recruited participants through two routes from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET.

RESULTS:

We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer's disease (AD), two with subcortical vascular dementia, two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia (FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET two with AD, one with mixed dementia, one with FTD, and one with CJD.

CONCLUSION:

The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Asia / Encéfalo / Imagen por Resonancia Magnética / Demencia Vascular / Estudios de Cohortes / Síndrome de Creutzfeldt-Jakob / Trastornos del Conocimiento / Afasia Progresiva Primaria / Enfermedades Neurodegenerativas / Demencia Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Yonsei Medical Journal Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Asia / Encéfalo / Imagen por Resonancia Magnética / Demencia Vascular / Estudios de Cohortes / Síndrome de Creutzfeldt-Jakob / Trastornos del Conocimiento / Afasia Progresiva Primaria / Enfermedades Neurodegenerativas / Demencia Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Yonsei Medical Journal Año: 2018 Tipo del documento: Artículo