Clinical Usefulness of Procalcitonin as Guideline of Antibiotic Treatment in Children with Respiratory Tract Infection / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
; : 110-115, 2012.
Article
en Ko
| WPRIM
| ID: wpr-71862
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Procalcitonin (PCT), a precursor of calcitonin, has been described as a biomarker of bacterial infection and inflammation. This study was performed to evaluate the clinical usefulness of PCT levels and to reduce the unnecessary usage of antibiotics in children with lower respiratory tract infection (RTI). METHODS: Eighty-eight children, with lower RTI, under the age of 5 years, who were admitted to Chungnam National University Hospital, between May 2010 and December 2010, were enrolled. White blood cell counts, erythrocyte sedimentation rate, C-reactive protein, and PCT were measured. Blood and sputum cultures were performed to identify the causative bacteria and reverse transcription-polymerase chain reaction for the viruses. Clinical features were reviewed, retrospectively. RESULTS: The mean participant age was 1.9+/-1.5 years. The cut-off value for serum PCT levels, which was derived from the receiver-operator characteristic curve, was 0.11 ng/mL. In 29 patients (33.0%) with low PCT levels ( or =0.11 ng/mL), hospitalization (P=0.005) and fever (P=0.054) exhibited a shorter duration, after antibiotic therapy. CONCLUSION: A single initial serum PCT levels (> or =0.11 ng/mL) may be clinically useful to give a guideline for antibiotic treatment in children with lower respiratory tract infection and to reduce the unnecessary usage of antibiotics.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Precursores de Proteínas
/
Sistema Respiratorio
/
Infecciones del Sistema Respiratorio
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Esputo
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Bacterias
/
Infecciones Bacterianas
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Sedimentación Sanguínea
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Proteína C-Reactiva
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Calcitonina
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Fiebre
Tipo de estudio:
Guideline
Límite:
Child
/
Humans
Idioma:
Ko
Revista:
Pediatric Allergy and Respiratory Disease
Año:
2012
Tipo del documento:
Article