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ABO Incompatible Living Donor Liver Transplantation: A Single Center Experience / 대한이식학회지
The Journal of the Korean Society for Transplantation ; : 84-91, 2018.
Artículo en Inglés | WPRIM | ID: wpr-718769
ABSTRACT

BACKGROUND:

This study examined the outcomes of ABO incompatible living donor liver transplantation (LDLT). The changes in the immunologic factors that might help predict the long term outcomes were also studied.

METHODS:

Twenty-three patients, who underwent ABO incompatible LDLT from 2010 to 2015, were reviewed retrospectively. The protocol was the same as for ABO compatible LDLT except for the administration of rituximab and plasma exchange. The clinical outcomes and immunologic factors, such as isoagglutinin titer and cluster of differentiation 20+ (CD20+) lymphocyte levels were reviewed.

RESULTS:

The center showed a 3-year survival of 64% with no case of antibody-mediated rejection. When transplantation-unrelated mortalities (for example, traffic accidents and myocardial infarction) were removed from statistical analysis, the 3-year survival was 77.8%. Although isoagglutinin titers continued to remain at low levels, the CD20+ lymphocyte levels recovered to the pre-Rituximab levels at postoperative one year.

CONCLUSIONS:

As donor shortages continue, ABO incompatible liver transplantation is a feasible method to expand the donor pool. On the other hand, caution is still needed until more long-term outcomes are reported. Because CD20+ lymphocytes are recovered with time, more immunologic studies will be needed in the future.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Intercambio Plasmático / Donantes de Tejidos / Sistema del Grupo Sanguíneo ABO / Linfocitos B / Linfocitos / Accidentes de Tránsito / Estudios Retrospectivos / Mortalidad / Trasplante de Hígado / Donadores Vivos Tipo de estudio: Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: The Journal of the Korean Society for Transplantation Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Intercambio Plasmático / Donantes de Tejidos / Sistema del Grupo Sanguíneo ABO / Linfocitos B / Linfocitos / Accidentes de Tránsito / Estudios Retrospectivos / Mortalidad / Trasplante de Hígado / Donadores Vivos Tipo de estudio: Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: The Journal of the Korean Society for Transplantation Año: 2018 Tipo del documento: Artículo