Prediction of Coronary Heart Disease Risk in Korean Patients with Diabetes Mellitus
Journal of Lipid and Atherosclerosis
;
: 110-121, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-718926
ABSTRACT
OBJECTIVE:
We developed a new equation for predicting coronary heart disease (CHD) risk in Korean diabetic patients using a hospital-based cohort and compared it with a UK Prospective Diabetes Study (UKPDS) risk engine.METHODS:
By considering patients with type 2 diabetes aged ≥30 years visiting the diabetic center in Boramae hospital in 2006, we developed a multivariable equation for predicting CHD events using the Cox proportional hazard model. Those with CHD were excluded. The predictability of CHD events over 6 years was evaluated using area under the receiver operating characteristic (AUROC) curves, which were compared using the DeLong test.RESULTS:
A total of 732 participants (304 males and 428 females; mean age, 60±10 years; mean duration of diabetes, 10±7 years) were followed up for 76 months (range, 1–99 month). During the study period, 48 patients (6.6%) experienced CHD events. The AUROC of the proposed equation for predicting 6-year CHD events was 0.721 (95% confidence interval [CI], 0.641–0.800), which is significantly larger than that of the UKPDS risk engine (0.578; 95% CI, 0.482–0.675; p from DeLong test=0.001). Among the subjects with <5% of risk based on the proposed equation, 30.6% (121 out of 396) were classified as ≥10% of risk based on the UKPDS risk engine, and their event rate was only 3.3% over 6 years.CONCLUSION:
The UKPDS risk engine overestimated CHD risk in type 2 diabetic patients in this cohort, and the proposed equation has superior predictability for CHD risk compared to the UKPDS risk engine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Modelos de Riesgos Proporcionales
/
Estudios Prospectivos
/
Curva ROC
/
Estudios de Cohortes
/
Enfermedad Coronaria
/
Diabetes Mellitus
/
Corea (Geográfico)
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Lipid and Atherosclerosis
Año:
2018
Tipo del documento:
Artículo
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