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Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche
Annals of Pediatric Endocrinology & Metabolism ; : 210-214, 2018.
Artículo en Inglés | WPRIM | ID: wpr-719221
ABSTRACT

PURPOSE:

Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5–8 years) and age and body mass index (BMI) matched controls.

METHODS:

Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done.

RESULTS:

PA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/m2). Dehydroepiandrostenedione sulfate (63.3±51.3 μg/dL vs. 29.8±17.3 μg/dL, P < 0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values ( < 14 years reference range, 0.49–3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups.

CONCLUSIONS:

Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndrome del Ovario Poliquístico / Valores de Referencia / Testosterona / Hispánicos o Latinos / Índice de Masa Corporal / Estudios Retrospectivos / Estudios de Cohortes / 17-alfa-Hidroxiprogesterona / Adrenarquia / Hormona Antimülleriana Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Límite: Niño / Femenino / Humanos Idioma: Inglés Revista: Annals of Pediatric Endocrinology & Metabolism Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndrome del Ovario Poliquístico / Valores de Referencia / Testosterona / Hispánicos o Latinos / Índice de Masa Corporal / Estudios Retrospectivos / Estudios de Cohortes / 17-alfa-Hidroxiprogesterona / Adrenarquia / Hormona Antimülleriana Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Límite: Niño / Femenino / Humanos Idioma: Inglés Revista: Annals of Pediatric Endocrinology & Metabolism Año: 2018 Tipo del documento: Artículo