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Efficacy of Alpha Blocker Treatment According to the Degree of Intravesical Prostatic Protrusion Detected by Transrectal Ultrasonography in Patients with Benign Prostatic Hyperplasia
Korean Journal of Urology ; : 92-97, 2012.
Artículo en Inglés | WPRIM | ID: wpr-71964
ABSTRACT

PURPOSE:

To analyze the effectiveness of tamsulosin 0.2 mg once daily for 3 months according to the degree of intravesical prostatic protrusion (IPP) in patients with benign prostatic hyperplasia (BPH). MATERIALS AND

METHODS:

A total of 134 BPH patients over 40 years of age treated with tamsulosin 0.2 mg between January 2007 and January 2009 were enrolled retrospectively. The patients were classified into three groups according to the degree of IPP below 5 mm (group A), between 5 and 10 mm (group B), and over 10 mm (group C). Prostate volume, prostate-specific antigen (PSA), prostatic urethral length (PUL), and prostatic adenoma urethral length (PAUL) were evaluated before treatment. International Prostate Symptom Score and Quality of Life (IPSS/QoL), maximal urine flow rate (Qmax), and postvoid residual (PVR) volume were measured before treatment, and improvement in the three groups was compared after 3 months.

RESULTS:

The mean age of the patients was 65.01+/-7.38 years. Mean IPPs were 0.90+/-1.39 mm (group A, n=90), 6.92+/-1.10 mm (group B, n=24), and 16.60+/-4.06 mm (group C, n=20). Prostate volume, PUL, PAUL, PSA, Qmax, and PVR showed significant correlations with IPP (p0.05). Comparison of parameters before and after 3 months showed that medication improved total IPSS and subscores (p<0.001), QoL (p<0.001), Qmax (p<0.001), and PVR (p=0.030) in group A. In group B, it improved total IPSS (p=0.01), irritative subscore (p<0.001), and obstructive subscore (p=0.03). In group C, only total IPSS (p=0.01) and irritative score (p<0.001) were significantly improved.

CONCLUSIONS:

Tamsulosin may be more effective in improving symptom scores and Qmax in patients with mild IPP than in those with moderate or severe IPP.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Próstata / Hiperplasia Prostática / Calidad de Vida / Sulfonamidas / Estudios Retrospectivos / Antígeno Prostático Específico / Indoles Tipo de estudio: Estudio observacional Límite: Humanos Idioma: Inglés Revista: Korean Journal of Urology Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Próstata / Hiperplasia Prostática / Calidad de Vida / Sulfonamidas / Estudios Retrospectivos / Antígeno Prostático Específico / Indoles Tipo de estudio: Estudio observacional Límite: Humanos Idioma: Inglés Revista: Korean Journal of Urology Año: 2012 Tipo del documento: Artículo