Effect of Etanercept on Steroid Refractory Graft-versus-host Disease in Children
Korean Journal of Hematology
; : 212-219, 2009.
Article
en Ko
| WPRIM
| ID: wpr-720082
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Etanercept is a recombinant human soluble tumor necrosis factor-alpha (TNF-alpha) receptor fusion protein that inhibits TNF-alpha, a major mediator in the pathogenesis of graft-versus-host disease (GVHD). The purpose of our study was to evaluate the safety and efficacy of etanercept therapy in children with steroid-refractory acute GVHD (aGVHD) (n=5) and chronic GVHD (cGVHD) (n=3). METHODS: Five males and 3 females were enrolled and their median age was 14.4 years (range, 2.1~18.8). Etanercept 0.4 mg/kg per dose (maximum dose, 25 mg) was given subcutaneously twice weekly for 4 weeks followed by 0.4 mg/kg per dose (maximum dose, 25 mg) weekly for 4 weeks. At the time of initiation of etanercept, 5 patients had aGVHD grade III to IV (III=4, IV=1) and 3 patients had moderate to severe cGVHD (moderate=1, severe=2). RESULTS: Overall, 6 of 8 patients (75%) responded to the treatment with etanercept, including 5 patients with aGVHD [n=3 complete response (CR), n=2 partial response (PR)] and 1 patient with cGVHD [n=1 PR, n=2 no response (NR)]. Clinical responses were most commonly seen in patients with refractory gut aGVHD. CMV reactivation occurred in 2 patients, bacterial infection in 1 patient, and fungal infection in 1 patient. CONCLUSION: Our preliminary data indicate that etanercept is well tolerated and can induce a high response rate in patients with steroid refractory aGVHD, particularly in the setting of intestinal involvement.
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Índice:
WPRIM
Asunto principal:
Infecciones Bacterianas
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Inmunoglobulina G
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Factor de Necrosis Tumoral alfa
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Receptores del Factor de Necrosis Tumoral
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Trasplante de Células Madre Hematopoyéticas
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Etanercept
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Enfermedad Injerto contra Huésped
Límite:
Child
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Female
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Humans
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Male
Idioma:
Ko
Revista:
Korean Journal of Hematology
Año:
2009
Tipo del documento:
Article