Characterization of antiphospholipid antibodies in chronic hepatitis B infection
Korean Journal of Hematology
; : 36-40, 2011.
Article
en En
| WPRIM
| ID: wpr-720123
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Many infections are associated with antiphospholipid antibodies (aPLs). The purpose of this study was to investigate the prevalence, persistence, clinical significance, and characteristics of aPLs in hepatitis B virus (HBV)-infected patients. METHODS: This study included 143 patients with HBV infection and 32 healthy individuals as controls. The presence of anticardiolipin antibodies (aCL Ab), anti-beta2-glycoprotein I antibodies (beta2GPI Ab), and lupus anticoagulant (LA) was assessed. RESULTS: The total prevalence of aPLs in HBV-infected patients was 12.6% (18 of 143). Of these 18 patients, 15 had low to medium titers of aCL Ab (10 with IgM, 4 with IgG, and 1 with both isotypes). beta2GPI Ab and LA were detected in 3 (2.1%) and 2 (1.4%) patients with HBV infection, respectively. In follow-up specimens from 14 patients with elevated levels of aCL Ab or beta2GPI Ab, 10 (71.4%) showed the persistent presence of aPLs. No clinical manifestations related to aPLs were identified. CONCLUSION: In HBV-infected patients, the most frequently detected antiphospholipid antibodies were IgM aCL Ab, which have a weak association with the clinical manifestations of APS. Unlike the transient presence reported for other infection-associated aPLs, most aPLs were persistently detected over a 12-week period in patients with HBV infection.
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Texto completo:
1
Índice:
WPRIM
Asunto principal:
Inmunoglobulina G
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Inmunoglobulina M
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Virus de la Hepatitis B
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Prevalencia
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Estudios de Seguimiento
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Inhibidor de Coagulación del Lupus
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Anticuerpos Antifosfolípidos
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Anticuerpos Anticardiolipina
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Hepatitis B Crónica
/
Hepatitis Crónica
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Korean Journal of Hematology
Año:
2011
Tipo del documento:
Article