Susceptibility of Leukemia according to the Genotype of Minor Histocompatibility Antigens in a Korean Population
Korean Journal of Hematology
;
: 15-23, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-720142
ABSTRACT
BACKGROUND:
In the search for susceptibility genes responsible for leukemia, genetic studies involving HLA association have been in progress extensively since the first report on its effect on the disease. Here we investigated the genetic associations of different leukemias with 4 autosomal mHags, HA-1, -2, -8 and HB-1. In particular, HB-1 is one of the leukemia-associated minor histocompatibility antigens (mHags) that is significantly expressed by Epstein-Barr virus-transformed- and tumor cells of all B lineage acute lymphoblastic leukemia (ALL).METHODS:
A simultaneous genotyping method using PCR sequence-specific primers against HA-1, -2, -8 and HB-1 was developed, and their allelic frequencies in 139 healthy controls and 36 leukemia patients were observed. To compare genotype, phenotype, and gene frequencies of mHags with healthy controls, leukemia patients were classified into sub groups of ALL, acute myeloid leukemia (AML), and chronic myeloid leukemia (CML).RESULTS:
The genotype frequencies of HA-1, -2 and -8 were not significantly different from healthy controls in every group of leukemia patients. However, the HB-1 H genotype was significantly increased in leukemia patients (P=0.03, OR=1.82, CI=1.08~3.06), particularly in AML (P=0.01, OR=2.4, CI=1.21~4.76) as compared with healthy controls.CONCLUSION:
Our results suggested that the genotype of HB-1 H may be associated with leukemia, particularly with AML. In further study, it is necessary to confirm the association of HB-1 with other leukemias in a larger group of patients, and to identify the underlying mechanism of HB-1 responsible for the occurrence of leukemia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Leucemia Mieloide Aguda
/
Leucemia
/
Antígenos de Histocompatibilidad Menor
/
Reacción en Cadena de la Polimerasa
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Frecuencia de los Genes
/
Genotipo
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Año:
2007
Tipo del documento:
Artículo
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