Long-term outcome of isolated thrombocytopenia accompanied by hypocellular marrow
Korean Journal of Hematology
;
: 128-134, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-720300
ABSTRACT
BACKGROUND:
Hypocellularity of bone marrow (BM), not associated with significant dyshematopoiesis, is often found in patients with isolated thrombocytopenia, but its clinical implications have not been studied. We prospectively studied the clinical features and natural history of these patients.METHODS:
Adults with isolated thrombocytopenia (platelet counts 50x10(9)/L in 16 patients (80%). BM cellularity ranged from 5% to 25% (median, 15%) and was 150x10(9)/L) after 12, 56 and 66 months. Three patients developed pancytopenia after 11, 70 and 90 months. Two patients were consistent with moderate aplastic anemia, and 1 was confirmed as having refractory cytopenia with multilineage dysplasia. In the remainder of the patients, platelet counts remained unchanged.CONCLUSION:
Isolated thrombocytopenia accompanied by hypocellular marrow encompasses a group of heterogeneous conditions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pancitopenia
/
Recuento de Plaquetas
/
Trombocitopenia
/
Médula Ósea
/
Síndromes Mielodisplásicos
/
Estudios Prospectivos
/
Estudios de Seguimiento
/
Aberraciones Cromosómicas
/
Púrpura Trombocitopénica Idiopática
/
Historia Natural
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Korean Journal of Hematology
Año:
2011
Tipo del documento:
Artículo
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