Biochemical Characteristics of Dysfunctional Fibrinogen Found in Korea
Korean Journal of Hematology
;
: 34-40, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-720451
ABSTRACT
BACKGROUND:
Hereditary dysfibrinogenemia is a rare cause of venous thromboembolism. Hereditary thrombophilia is diagnosed in about 10% of patients with thromboembolism, with the prevalence diagnosed increasing with the development of molecular biological method.METHODS:
A 27-year-old woman was strongly suspected to have hereditary dysfibrinogenemia; therfore, an analysis of the molecular structure of the purified fibrinogen was performed.RESULTS:
An SDS-PAGE analysis of the purified fibrinogen revealed no abnormal finding. The purified fibrinogen was treated with thrombin or coagulation factor XIII, and the products show no difference between the normal and patient's specimen on SDS-PAGE analysis. However, an HPLC analysis showed an additional abnormal peak prior to the normal fibrinopeptid A peak.CONCLUSION:
A dysfunctional fibrinogen showing an abnormal peak on HPLC analysis was detected in a Korean patient. Her family also showed dysfunctional fibrinogen. In a Korean patient with recurrent thromboembolism, hereditary dysfibrinogenemia should also be taken into consideration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tromboembolia
/
Factor XIII
/
Fibrinógeno
/
Trombina
/
Estructura Molecular
/
Prevalencia
/
Cromatografía Líquida de Alta Presión
/
Trombofilia
/
Electroforesis en Gel de Poliacrilamida
/
Tromboembolia Venosa
Tipo de estudio:
Estudio de prevalencia
Límite:
Adulto
/
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Año:
2005
Tipo del documento:
Artículo
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