Incidence and clinical characteristics of clonal cytogenetic abnormalities of acquired aplastic anemia in adults
Korean Journal of Hematology
;
: 242-246, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-720659
ABSTRACT
BACKGROUND:
Cytogenetic abnormalities (CAs) have been reported frequently in patients with otherwise typical aplastic anemia (AA), but their implications in the prognosis and in the evolution to hematologic malignancies are controversial.METHODS:
We retrospectively analyzed 127 adult AA patients who had successful cytogenetic analysis at initial diagnosis.RESULTS:
The patients were classified into 3 groups according to the initial and follow-up results of cytogenetic profiles. Group 1 included patients who had persistent AA with normal cytogenetic profiles (N=117); Group 2, those who had a normal cytogenetic profile at initial diagnosis but later acquired CA (N=4, 3.1%); and Group 3, those who had CA at the initial diagnosis, regardless of follow-up cytogenetic status (N=6,4.7%). In Group 2, 2 patients later developed CA without progression to acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS); the other 2 patients later progressed to AML. None of the patients in Group 3 progressed to AML or MDS. There was no significant difference in overall survival between Groups 1 and 3.CONCLUSION:
AA patients with CA at initial diagnosis or follow-up may not be at greater risk for evolution to AML or MDS, or show shorter survival periods. Prospective studies and a larger patient samples are needed to establish the clinical relevance of CA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Síndromes Mielodisplásicos
/
Leucemia Mieloide Aguda
/
Incidencia
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Aberraciones Cromosómicas
/
Neoplasias Hematológicas
/
Análisis Citogenético
/
Citogenética
Tipo de estudio:
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Hematology
Año:
2010
Tipo del documento:
Artículo
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