FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
Korean Journal of Hematology
;
: 250-257, 2007.
Artículo
en Inglés
| WPRIM
| ID: wpr-720788
ABSTRACT
BACKGROUND:
The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.METHODS:
The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.RESULTS:
Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.CONCLUSION:
This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Médula Ósea
/
Leucemia Mieloide Aguda
/
Reacción en Cadena de la Polimerasa
/
Análisis Multivariante
/
Diagnóstico
/
Quimioterapia de Inducción
/
Cariotipo
/
Recuento de Leucocitos
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Hematology
Año:
2007
Tipo del documento:
Artículo
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