Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo
Nutrition Research and Practice
;
: 294-300, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-72113
ABSTRACT
We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 micromol/L) of resveratrol. For experimental metastasis, BALB/c mice were injected intravenously with 4T1 cells in the tail vein, and were orally administered various concentrations (0, 100, or 200 mg/kg Body weight) of resveratrol for 21 days. After resveratrol treatment, cell adhesion, wound migration, invasion, and MMP-9 activity were significantly decreased in a dose-dependent manner in 4T1 cells (P < 0.05). The numbers of pulmonary nodules were significantly decreased in mice fed the resveratrol (P < 0.05). The plasma MMP-9 activity was decreased in response to treatment with resveratrol in mice (P < 0.05). We conclude that resveratrol inhibits cancer metastasis both in vitro and in vivo, and this inhibition is likely due to the decrease in MMP-9 activity caused by resveratrol.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Estilbenos
/
Venas
/
Mama
/
Neoplasias de la Mama
/
Adhesión Celular
/
Metaloproteinasa 9 de la Matriz
/
Metástasis de la Neoplasia
Límite:
Animales
Idioma:
Inglés
Revista:
Nutrition Research and Practice
Año:
2012
Tipo del documento:
Artículo
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