Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis / 한국역학회지
Epidemiology and Health
;
: e2015005-2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-721186
ABSTRACT
OBJECTIVES:
Although an expert review published in 2013 concluded that an association between human papillomavirus (HPV) infection and prostate cancer (PCa) risk had not yet been firmly established, a 2011 systematic review of 14 articles revealed an increased prevalence of HPV-16 DNA in PCa tissues. Another meta-analysis of the related articles is needed to evaluate the potential link between HPV infection and PCa risk.METHODS:
A snowballing search strategy was applied to the previously cited articles in the above-mentioned expert review and systematic review. Additional articles selected for this meta-analysis should fulfill all following inclusion criteria (a) evaluation of detected HPV-16 DNA in tissue samples and the PCa risk and (b) report of the HPV-16 prevalence in both cancer and control tissues. Estimated summary odds ratios (sOR) with 95% confidence intervals (CI) were calculated using fixed effect or random-effect models.RESULTS:
Hand searching identified 16 new articles. The sOR of the total 30 articles indicated a significant HPV-16 infection-related increase in the PCa risk (sOR, 1.851; 95% CI, 1.353 to 2.532, I2=37.82%).CONCLUSIONS:
These facts provide additional supportive evidence for a causal role of HPV-16 infection in prostate carcinogenesis. As the PCa incidence rates have increased rapidly in Asian countries, including Korea, during the last several decades, further studies of HPV-related PCa carcinogenesis may be necessary.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virus Oncogénicos
/
Próstata
/
Neoplasias de la Próstata
/
ADN
/
Anafilaxis Cutánea Pasiva
/
Oportunidad Relativa
/
Incidencia
/
Prevalencia
/
Factores de Riesgo
/
Pueblo Asiatico
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Epidemiology and Health
Año:
2015
Tipo del documento:
Artículo
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