Adjusting for reverse causation to estimate the effect of obesity on mortality after incident heart failure in the Atherosclerosis Risk in Communities (ARIC) study / 한국역학회지
Epidemiology and Health
;
: e2016025-2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-721331
ABSTRACT
OBJECTIVES:
The lower mortality rate of obese patients with heart failure (HF) has been partly attributed to reverse causation bias due to weight loss caused by disease. Using data about weight both before and after HF, this study aimed to adjust for reverse causation and examine the association of obesity both before and after HF with mortality.METHODS:
Using the Atherosclerosis Risk in Communities (ARIC) study, 308 patients with data available from before and after the incidence of HF were included. Pre-morbid and post-morbid obesity were defined based on body mass index measurements at least three months before and after incident HF. The associations of pre-morbid and post-morbid obesity and weight change with survival after HF were evaluated using a Cox proportional hazard model.RESULTS:
Pre-morbid obesity was associated with higher mortality (hazard ratio [HR], 1.61; 95% confidence interval [CI], 1.04 to 2.49) but post-morbid obesity was associated with increased survival (HR, 0.57; 95% CI, 0.37 to 0.88). Adjusting for weight change due to disease as a confounder of the obesity-mortality relationship resulted in the absence of any significant associations between post-morbid obesity and mortality.CONCLUSIONS:
This study demonstrated that controlling for reverse causality by adjusting for the confounder of weight change may remove or reverse the protective effect of obesity on mortality among patients with incident HF.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pérdida de Peso
/
Sesgo
/
Índice de Masa Corporal
/
Modelos de Riesgos Proporcionales
/
Incidencia
/
Mortalidad
/
Aterosclerosis
/
Corazón
/
Insuficiencia Cardíaca
/
Obesidad
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Epidemiology and Health
Año:
2016
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS