Epidemiology, Microbiological and Clinical Features, Treatment, and Outcomes of Infective Endocarditis in Crete, Greece / 감염과화학요법
Infection and Chemotherapy
;
: 21-28, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-721720
ABSTRACT
BACKGROUND:
This study aimed to evaluate the epidemiology, clinical and microbiological features, treatment, and outcomes of infective endocarditis (IE) on the island of Crete, a region with high levels of antimicrobial resistance. MATERIALS ANDMETHODS:
Medical records of all hospitalized patients diagnosed with IE at the University Hospital of Heraklion, Crete, Greece, from 1995 to 2015, were retrospectively reviewed. Patients who met the modified Duke's criteria for definite or possible IE were included.RESULTS:
A total of 82 IE patients (median age 67 [range 21–86] years) were included. Most patients suffered from left-sided IE (94%), while most cases of infection occurred in native valves (53.6%). Systemic inflammatory response syndrome criteria were lacking in almost half of the patient population. The leading causative microorganism was Staphylococcus aureus, isolated in 24 cases (29%), followed by Streptococcus spp. in 15 (18%) and Enterococcus spp. in 12 (14.5%). A number of rare and difficult to treat microorganisms had been identified, such as Gemella morbillorum in four cases (4.5%), Streptococcus lugdunensis in two (2.5%) and Streptococcus pneumoniae in one (1%). One patient was serologically positive for Coxiella burnetii (1%). All patients received empirical antimicrobial treatment, proven appropriate in 39 blood culture-positive patients (56.5%). Thirteen (16%) patients were classified as culture negative. Seven patients (8.5%) were surgically treated. In-hospital death occurred in 9 patients (11%).CONCLUSION:
Changes in IE profile requires continuous epidemiological updates. Staphylococcus and Streptococcus spp. remain the most common etiologic agents. However, the presence of uncommon and/or difficult to treat pathogens raise concerns on the appropriate prophylaxis as well as empirical treatment.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Staphylococcus
/
Staphylococcus aureus
/
Streptococcus
/
Streptococcus pneumoniae
/
Registros Médicos
/
Epidemiología
/
Estudios Retrospectivos
/
Resultado del Tratamiento
/
Enterococcus
/
Coxiella burnetii
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Humanos
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Infection and Chemotherapy
Año:
2018
Tipo del documento:
Artículo
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