Evaluation of a New Diagnostic Test for Invasive Fungal Infections Using Prophenoloxydase System to Measure (1->3)-beta-D-glucan Concentration / 감염과화학요법
Infection and Chemotherapy
;
: 146-153, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-721981
ABSTRACT
BACKGROUND:
Prognosis of invasive fungal infection is supposed to be better when diagnosed earlier. (1->3)-beta-D-glucan (BDG) test is considered useful in early diagnosis of invasive fungal infections among high-risk patients. A new diagnostic test using prophenoloxydase system to measure BDG level is developed. A study was performed to evaluate clinical usefulness of this new diagnostic test. MATERIALS ANDMETHODS:
15 patients of confirmed invasive fungal infections and 38 healthy normal volunteers were enrolled. Plasma or serum BDG concentrations were measured using prophenoloxydase system. Assays for intra-run variability and inter-run variability were performed. A cut-off value was determined and sensitivity and specificity of the test were evaluated.RESULTS:
A cut-off value of 94.90 pg/mL was determined. Sensitivity and specificity of the test were 86.7% and 52.6%, respectively. Statistical analyses of inter-run variability and intra-run variability revealed the test is reliable (P< or =0.001).CONCLUSION:
BDG test using prophenoloxydase system is a sensitive and reliable test in non-invasive detection of invasive fungal infection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Pronóstico
/
Sensibilidad y Especificidad
/
Diagnóstico Precoz
/
Pruebas Diagnósticas de Rutina
/
Voluntarios Sanos
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Coreano
Revista:
Infection and Chemotherapy
Año:
2006
Tipo del documento:
Artículo
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