The Change of Bone Metabolism in Stroke Rat
Journal of the Korean Academy of Rehabilitation Medicine
;
: 163-168, 2004.
Artículo
en Coreano
| WPRIM
| ID: wpr-723910
ABSTRACT
OBJECTIVE:
The purpose of this study was to investigate the effect of ischemic stroke on bone metabolism.METHOD:
Female Sprague-Dawley rats (12 weeks old, n=48) were randomly divided into 4 separate groups; sham operation group (group A), stroke group (group B), ovariectomy group (group C), and stroke-ovariectomy group (group D). Two weeks after performing ovariectomy, cerebral ischemia was induced. The bone mineral density (BMD) and osteocalcin and carboxy-terminal telopeptide (CTX) were measured on three periods the day before ischemia and 1 and 3 weeks post-stroke. All data were statistically analyzed.RESULTS:
One week after cerebral ischemia, lumbar spine BMD of group B and D although statistically insignificant showed a lower BMD score in comparison to group A and C, respectively. Three weeks after ischemia, compared to group C, the BMD score of lumbar spine in group D was reduced significantly (p<0.05). At one week post-stroke, compared with group A and C, the value of osteocalcin in group B and D were reduced significantly, respectively (p<0.05). One and three weeks after ischemia, the CTX value in all groups showed no statistical difference.CONCLUSION:
The authors concluded that ischemic stroke affected bone metabolism by decreasing osteoblastic activity in the early phase of stroke rat.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoblastos
/
Osteoporosis
/
Columna Vertebral
/
Ovariectomía
/
Densidad Ósea
/
Osteocalcina
/
Isquemia Encefálica
/
Ratas Sprague-Dawley
/
Accidente Cerebrovascular
/
Modelos Animales
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Academy of Rehabilitation Medicine
Año:
2004
Tipo del documento:
Artículo
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