Knockdown of 14-3-3zeta enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells
Experimental & Molecular Medicine
;
: e77-2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-72396
ABSTRACT
14-3-3zeta is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3zeta decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3zeta affects the radioresistance of cancer stem-like cells (CSCs) in HCC. Knockdown of 14-3-3zeta decreased cell viability and the number of spheres by reducing radioresistance in CSCs after gamma-irradiation (IR). Furthermore, the levels of pro-apoptotic proteins were upregulated in CSCs via silencing 14-3-3zeta after IR. These results suggest that 14-3-3zeta knockdown enhances radio-induced apoptosis by reducing radioresistance in liver CSCs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptidos
/
Tolerancia a Radiación
/
Células Madre Neoplásicas
/
Glicoproteínas
/
Antígenos CD
/
Carcinoma Hepatocelular
/
Línea Celular Tumoral
/
Proteínas 14-3-3
/
Proteínas Reguladoras de la Apoptosis
/
Rayos gamma
Límite:
Humanos
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2014
Tipo del documento:
Artículo
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