Venlafaxine-Induced Acute Toxic Hepatitis
Journal of the Korean Society of Biological Psychiatry
;
: 159-162, 2011.
Artículo
en Coreano
| WPRIM
| ID: wpr-725334
ABSTRACT
Venlafaxine is among the most widely prescribed antidepressants. It is extensively metabolized to O-desmethylvenlafaxine via cytochrome P450 (CYP) 2D6. We report a case of acute toxic hepatitis resulting from venlafaxine in a 54-year-old woman with pain disorder. During venlafaxine treatment, laboratory tests revealed elevated liver enzymes with a maximum of 169 IU/L for aspartate transaminase (AST) and 166 IU/L for alanine transaminase (ALT). AST and ALT levels returned to normal after 6 days of discontinuation of venlafaxine. The patient was finally diagnosed with acute toxic hepatitis through liver biopsy. This case indicates the importance that clinicians should be aware of the hepatotoxicity of venlafaxine in practice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aspartato Aminotransferasas
/
Trastornos Somatomorfos
/
Biopsia
/
Ciclohexanoles
/
Sistema Enzimático del Citocromo P-450
/
Alanina Transaminasa
/
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Succinato de Desvenlafaxina
/
Clorhidrato de Venlafaxina
Límite:
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Psychiatry
Año:
2011
Tipo del documento:
Artículo
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