Efficacy of VP2 protein expressed in E. coli for protection against highly virulent infectious bursal disease virus
Journal of Veterinary Science
;
: 241-247, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-72559
ABSTRACT
The ability of a heat-inactivated whole virus from a highly virulent infectious bursal disease virus (hvIBDV) and VP2 protein from hvIBDV expressed in E. coli provided protection against a hvIBDV challenge in specificpathogen- free (SPF) chickens. Six out of seven chickens that were injected three times with crude VP2 protein developed significant antibody titer against IBDV. However, only four out of the seven chickens survived the hvIBDV challenge. Despite showing low antibody titer profiles, all chickens immunized with the heat-inactivated whole virus also survived the challenged with hvIBDV. However, all of these chickens had bursal atrophy and mild to moderate depletion of lymphocytes. Thus, antibodies raised against IBDV VP2 protein expressed in E. coli and denatured IBDV proteins induced some degree of protection against mortality but not against bursal damage following challenge with hvIBDV.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedades de las Aves de Corral
/
Proteínas Recombinantes
/
Ensayo de Inmunoadsorción Enzimática
/
Vacunas Atenuadas
/
Vacunas Virales
/
Vacunas Sintéticas
/
Proteínas Estructurales Virales
/
Pollos
/
Inmunización
/
Organismos Libres de Patógenos Específicos
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2006
Tipo del documento:
Artículo
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