Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats
Journal of Veterinary Science
;
: 229-232, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-72561
ABSTRACT
Spigelia anthelmia Linn is used as a herb and is a common annual weed of cultivation in open re-growths, on unused land in towns as well as on road sides. The plant can grow to approximately 30 cm in height. The aim of this study was to screen extracts of Spigelia anthelmia for their anthelmintic activity against an experimental Nippostrongylus braziliensis infection in rats. Acute oral toxicity occurred at a dose of 1,140 mg/kg, while anthelmintic trials against Nippostrongylus braziliensis in rats using the aqueous fraction showed a progressive decrease in worm count with increasing dose (10, 13, 16, 20 and 25 mg per kg body weight) (p < 0.05). At 25 mg per kg body weight, the worm count was significantly lower than that at 10 mg per kg body weight (p < 0.05).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Extractos Vegetales
/
Medicinas Tradicionales Africanas
/
Infecciones por Strongylida
/
Ratas Wistar
/
Loganiaceae
/
Evaluación Preclínica de Medicamentos
/
Dosificación Letal Mediana
/
Fitoterapia
/
Antihelmínticos
/
Nigeria
Límite:
Animales
País/Región como asunto:
Africa
/
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2006
Tipo del documento:
Artículo
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