Cytologic Evaluation of Adenocarcinoma and its Mimics in Sputum and Bronchial Washings / 대한세포병리학회지
Korean Journal of Cytopathology
;
: 36-45, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-726231
ABSTRACT
OBJECTIVE:
To identify key cytologic features for diagnosis of adenocarcinoma and morphologic differentiation from reactive/reparative respiratory epithelium. STUDYDESIGN:
The cytomorphologic features of 145 pulmonary cytology specimens (sputum and bronchial washing), which included 117 histologically proven adenocarcinomas and 28 non-neoplastic lesions, cytologically diagnosed as atypia and suspicious for malignancy (adenocarcinoma) were reviewed retrospectively. We analyzed 11 morphologic criteria in pulmonary cytologic specimens.RESULTS:
Over 110 of 117 cases of adenocarcinomas revealed nuclear membrane irregularities, non-cohesive cells, single atypical cells, moderate to markedly enlarged nuclei and an increased nuclear/cytoplasmic (N/C) ratio. Chromatin clearing, chromatin heterogeneity and hyperchromasia were seen in 102, 99 and 97 cases, respectively. All 28 cases involving non-neoplastic lesions revealed hyperplastic reactive pneumocytes, hyperplastic reactive bronchial epithelium, or degenerating macrophages. The non-neoplastic lesions revealed a small number of atypical cell clusters and paucity or absence of atypical single cells.CONCLUSION:
The most important morphologic features for diagnosis of adenocarcinoma are nuclear membrane irregularities, non-cohesive cells, single atypical cell, moderate to markedly enlarged nuclei and increased N/C ratio. Chromatin clearing, chromatin heterogeneity and hyperchromasia were also helpful features, while pleomorphism and prominent nucleoli were less valuable.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esputo
/
Características de la Población
/
Cromatina
/
Adenocarcinoma
/
Estudios Retrospectivos
/
Mucosa Respiratoria
/
Diagnóstico
/
Epitelio
/
Células Epiteliales Alveolares
/
Pulmón
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Coreano
Revista:
Korean Journal of Cytopathology
Año:
2007
Tipo del documento:
Artículo
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