A Case of Autoantibody-Positive Ketosis-Prone Diabetes Mellitus / 임상당뇨병
Journal of Korean Diabetes
; : 60-66, 2016.
Article
en Ko
| WPRIM
| ID: wpr-726754
Biblioteca responsable:
WPRO
ABSTRACT
Ketosis-prone diabetes mellitus (KPD), which is an atypical type of diabetic mellitus with severe β cell dysfunction, is accompanied by ketosis or ketoacidosis without specific preceding factors at diagnosis. KPD shows mixed features of type 1 and type 2 diabetes. In some cases, the recovery of the function of β cells during intensified diabetic management enabled the termination of insulin therapy. The Aβ classification system classifies KPD patients into four distinct subgroups depending upon the presence or absence of β cell autoimmunity and β cell functional reserve and has been recognized as an important tool to predict clinical outcomes. In Korea, several cases of KPD with absence of β cell autoimmunity have been reported. A 60-year-old man presenting with DKA (diabetic ketoacidosis) as the first manifestation of diabetes, was shown to have β cell autoimmunity. A significant improvement in glycemic control was shown as a result of aggressive diabetic management; shortly after an acute episode of DKA, the recovery of β cell functional reserve was confirmed. This result allowed discontinuation of insulin therapy and maintenance of euglycemic status without antidiabetic medication.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Autoinmunidad
/
Clasificación
/
Cetoacidosis Diabética
/
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
/
Diagnóstico
/
Insulina
/
Cetosis
/
Corea (Geográfico)
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Journal of Korean Diabetes
Año:
2016
Tipo del documento:
Article