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Clinical Application of Glucagon-Like Peptide-1 Receptor Agonists / 임상당뇨병
Journal of Korean Diabetes ; : 252-259, 2015.
Artículo en Coreano | WPRIM | ID: wpr-726854
ABSTRACT
Glucagon-like peptide 1 (GLP-1) is an incretin hormone that is released from enteroendocrine L-cells upon nutrient absorption; it stimulates glucose-dependent insulin secretion from pancreatic betacells. GLP-1 has pleiotropic effects including deceleration of gastric emptying, decreased appetite, and increased satiety. Treatment with GLP-1 receptor agonists (GLP-1RAs) improves glycemic control in patients with type 2 diabetes without increasing the risk of hypoglycemia or weight gain. Current GLP-1RAs can be classified by their structure (exendin-4-based or human GLP-1-based), duration of action, and molecular size. Different GLP-1RAs exhibit different pharmacokinetics and pharmacodynamics. Herein we review the characteristics of available GLP-1RAs and discuss current issues such as insulin combination therapy and anti-obesity effects.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apetito / Farmacocinética / Aumento de Peso / Desaceleración / Diabetes Mellitus Tipo 2 / Absorción / Péptido 1 Similar al Glucagón / Incretinas / Receptor del Péptido 1 Similar al Glucagón / Vaciamiento Gástrico Límite: Humanos Idioma: Coreano Revista: Journal of Korean Diabetes Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apetito / Farmacocinética / Aumento de Peso / Desaceleración / Diabetes Mellitus Tipo 2 / Absorción / Péptido 1 Similar al Glucagón / Incretinas / Receptor del Péptido 1 Similar al Glucagón / Vaciamiento Gástrico Límite: Humanos Idioma: Coreano Revista: Journal of Korean Diabetes Año: 2015 Tipo del documento: Artículo