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Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries
The Korean Journal of Physiology and Pharmacology ; : 51-57, 2010.
Artículo en Inglés | WPRIM | ID: wpr-727341
ABSTRACT
It was hypothesized that NaF induces calcium sensitization in Ca2+-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with beta-escin and subjected to tension measurement. NaF potentiated the concentration-response curves to Ca2+ (decreased EC50 and increased E(max)). Cumulative addition of NaF (4.0, 8.0 and 16 mM) also increased vascular tension in Ca2+-controlled solution at pCa 7.0 or pCa 6.5, but not at pCa 8.0. NaF-induced vasocontraction and GTPgammaS-induced vasocontraction were not additive. NaF-induced vasocontraction at pCa 7.0 was inhibited by pretreatment with Rho kinase inhibitors H1152 or Y27632 but not with a MLCK inhibitor ML-7 or a PKC inhibitor Ro31-8220. NaF induces calcium sensitization in a Ca2+-dependent manner in beta-escin-permeabilized rat mesenteric arteries. These results suggest that NaF is an activator of the Rho kinase signaling pathway during vascular contraction.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piridinas / Sodio / Fluoruro de Sodio / Azepinas / Anafilaxis Cutánea Pasiva / Calcio / Contratos / Escina / Quinasas Asociadas a rho / Amidas Límite: Animales Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piridinas / Sodio / Fluoruro de Sodio / Azepinas / Anafilaxis Cutánea Pasiva / Calcio / Contratos / Escina / Quinasas Asociadas a rho / Amidas Límite: Animales Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2010 Tipo del documento: Artículo