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Inhibition of Adenosine Triphosphate-stimulated Mucin Secretion from Airway Epithelial Cells by Schizandrin
The Korean Journal of Physiology and Pharmacology ; : 251-254, 2006.
Artículo en Inglés | WPRIM | ID: wpr-727447
ABSTRACT
Schizandrae Fructus has been used for controlling respiratory allergic or inflammatory diseases in folk medicine and their components, schizandrin, schizandrin-A and gomisin-A were reported to have diverse biological effects. In this study, we investigated whether schizandrin, schizandrin-A and gomisin-A affect adenosine triphosphate (ATP)-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin secretion. The results were as follows 1) schizandrin significantly inhibited ATP-induced mucin secretion; 2) However, schizandrin-A and gomisin-A did not affect ATP-induced mucin secretion, significantly. We conclude that schizandrin can inhibit ATP-induced mucin secretion by directly acting on airway mucin-secreting cells. Therefore, schizandrin should further be investigated for the possible use as mucoregulators in the treatment of inflammatory airway diseases.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Adenosina / Adenosina Trifosfato / Schisandra / Células Epiteliales / Medicina Tradicional / Mucinas Límite: Animales Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Adenosina / Adenosina Trifosfato / Schisandra / Células Epiteliales / Medicina Tradicional / Mucinas Límite: Animales Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2006 Tipo del documento: Artículo