Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse
The Korean Journal of Physiology and Pharmacology
;
: 33-39, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-727598
ABSTRACT
Shepherd's purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd's purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1beta [IL-1beta], IL-6, and IL-10), and prostaglandin E2 (PGE2) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti-inflammatory activity of SCS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was 250 microg/ml for VRE and 1,000 microg/ml for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and anti-superbacterial properties, and thus it can be used as a functional food or pharmaceutical.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Asia
/
Bacillus anthracis
/
Dinoprostona
/
Citocinas
/
Interleucina-6
/
Óxido Nítrico Sintasa
/
Capsella
/
Alimentos Funcionales
/
Ciclooxigenasa 2
/
Alimentos Orgánicos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2014
Tipo del documento:
Artículo
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