Melatonin enhances hepatic glutathione-peroxidase activity in Sprague-Dawley rats
The Korean Journal of Physiology and Pharmacology
;
: 221-224, 1997.
Artículo
en Inglés
| WPRIM
| ID: wpr-727648
ABSTRACT
Effects of melatonin on hepatic glutathione-peroxidase (GSH-Px) and glutathione-reductase (GSH-reductase) activities were studied in Sprague-Dawley (SD) rats administered i.p. (10 mg/kg body weight) with melatonin during 15 days. The activity of cytosolic GSH-reductase in the liver was not changed by melatonin. However, melatonin injection increased significantly the activity of liver cytosolic GSH-Px activity compared with those in saline-treated rats. At the same time, plasma GSH-Px was also increased significantly in melatonin-treated rats. Since GSH-Px, a major antioxidative enzyme, removes H-2O-2 and lipid peroxides which are formed during lipid peroxidation from cellular membrane, such elevation of heptatic GSH-Px activity may contribute to the improvement of antioxidative effects under oxidative damage in the liver.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Peroxidación de Lípido
/
Ratas Sprague-Dawley
/
Citosol
/
Peróxidos Lipídicos
/
Hígado
/
Melatonina
/
Membranas
Límite:
Animales
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
1997
Tipo del documento:
Artículo
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