Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men
The Korean Journal of Physiology and Pharmacology
;
: 441-446, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-727702
ABSTRACT
Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on skeletal muscle development and related factors in men. Sixteen healthy male participants (age, 29.37+/-5.14 years; body mass index=27.13+/-2.16 kg/m2) were randomly assigned to RT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of intervention consisting of 5 sets of 26 exercises, with 10~15 repetitions at 60~80% of 1 repetition maximum and a 60~90-s rest interval between sets, performed 6 times/week. UA or placebo was orally ingested as 1 capsule 3 times/day for 8 weeks. The following factors were measured pre-and post-intervention body composition, insulin, insulin-like growth factor-1 (IGF-1), irisin, and skeletal muscle strength. Body fat percentage was significantly decreased (p<0.001) in the RT+UA group, despite body weight, body mass index, lean body mass, glucose, and insulin levels remaining unchanged. IGF-1 and irisin were significantly increased compared with baseline levels in the RT+UA group (p<0.05). Maximal right and left extension (p<0.01), right flexion (p<0.05), and left flexion (p<0.001) were significantly increased compared with baseline levels in the RT+UA group. These findings suggest that UA-induced elevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strength during RT.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Composición Corporal
/
Peso Corporal
/
Factor I del Crecimiento Similar a la Insulina
/
Ejercicio Físico
/
Índice de Masa Corporal
/
Tejido Adiposo
/
Músculo Esquelético
/
Fuerza Muscular
/
Entrenamiento de Fuerza
/
Glucosa
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2014
Tipo del documento:
Artículo
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