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Bis is Induced by Oxidative Stress via Activation of HSF1
The Korean Journal of Physiology and Pharmacology ; : 403-409, 2014.
Artículo en Inglés | WPRIM | ID: wpr-727707
ABSTRACT
The Bis protein is known to be involved in a variety of cellular processes including apoptosis, migration, autophagy as well as protein quality control. Bis expression is induced in response to a number of types of stress, such as heat shock or a proteasome inhibitor via the activation of heat shock factor (HSF)1. We report herein that Bis expression is increased at the transcriptional level in HK-2 kidney tubular cells and A172 glioma cells by exposure to oxidative stress such as H2O2 treatment and oxygen-glucose deprivation, respectively. The pretreatment of HK-2 cells with N-acetyl cysteine, suppressed Bis induction. Furthermore, HSF1 silencing attenuated Bis expression that was induced by H2O2, accompaniedby increase in reactive oxygen species (ROS) accumulation. Using a series of deletion constructs of the bis gene promoter, two putative heat shock elements located in the proximal region of the bis gene promoter were found to be essential for the constitutive expression is as well as the inducible expression of Bis. Taken together, our results indicate that oxidative stress induces Bis expression at the transcriptional levels via activation of HSF1, which might confer an expansion of antioxidant capacity against pro-oxidant milieu. However, the possible role of the other cis-element in the induction of Bis remains to be determined.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Control de Calidad / Choque / Autofagia / Especies Reactivas de Oxígeno / Apoptosis / Estrés Oxidativo / Cisteína / Inhibidores de Proteasoma / Glioma / Calor Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Control de Calidad / Choque / Autofagia / Especies Reactivas de Oxígeno / Apoptosis / Estrés Oxidativo / Cisteína / Inhibidores de Proteasoma / Glioma / Calor Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2014 Tipo del documento: Artículo