Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse
The Korean Journal of Physiology and Pharmacology
;
: 359-365, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-727709
ABSTRACT
Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K+ conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretchactivated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Quinidina
/
Relajación
/
Acidosis
/
Contracción Uterina
/
Útero
/
4-Aminopiridina
/
Contratos
/
Concentración de Iones de Hidrógeno
/
Lidocaína
Límite:
Animales
/
Embarazo
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2013
Tipo del documento:
Artículo
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