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Effect of Lutein on L-NAME-Induced Hypertensive Rats
The Korean Journal of Physiology and Pharmacology ; : 339-345, 2013.
Artículo en Inglés | WPRIM | ID: wpr-727711
ABSTRACT
We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3+/-9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from 434+/-26 to 376+/-33 beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against L-NAME-induced hypertension in rats.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Luteína / Presión Sanguínea / Peroxidación de Lípido / Administración Oral / NG-Nitroarginina Metil Éster / Presión Arterial / Glutatión / Corazón / Frecuencia Cardíaca Límite: Animales Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Luteína / Presión Sanguínea / Peroxidación de Lípido / Administración Oral / NG-Nitroarginina Metil Éster / Presión Arterial / Glutatión / Corazón / Frecuencia Cardíaca Límite: Animales Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2013 Tipo del documento: Artículo