Dual action of d-tubocurarine on large-conductance Ca2+-activated K+ channels from rat brain reconstituted into planar lipid bilayer
The Korean Journal of Physiology and Pharmacology
;
: 549-553, 1998.
Artículo
en Inglés
| WPRIM
| ID: wpr-727762
ABSTRACT
Using the planar lipid bilayer method, we investigated the effect of d-tubocurarine (dTC) on the extracellular side of large-conductance Ca2+-activated K+ channel from rat brain. When the initial open probability (Po) of the channel was relatively high, dTC decreased channel activity in a concentration dependent manner. In contrast, when the initial Po was lower, sub-micro molar dTC increased channel activity by destabilizing the closed states of the channel. Further addition of dTC up to micro molar range decreased channel activity. This dual effect of dTC implicates that there exist at least two different binding sites for dTC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tubocurarina
/
Sitios de Unión
/
Encéfalo
/
Canales de Potasio Calcio-Activados
/
Membrana Dobles de Lípidos
/
Diente Molar
Límite:
Animales
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
1998
Tipo del documento:
Artículo
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