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Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial Cells
The Korean Journal of Physiology and Pharmacology ; : 119-124, 2015.
Artículo en Inglés | WPRIM | ID: wpr-727817
ABSTRACT
The aim of the present study was to assess whether exposure to the combination of an extremely low frequency magnetic field (ELF-MF; 60 Hz, 1 mT or 2 mT) with a stress factor, such as ionizing radiation (IR) or H2O2, results in genomic instability in non-tumorigenic human lung epithelial L132 cells. To this end, the percentages of G2/M-arrested cells and aneuploid cells were examined. Exposure to 0.5 Gy IR or 0.05 mM H2O2 for 9 h resulted in the highest levels of aneuploidy; however, no cells were observed in the subG1 phase, which indicated the absence of apoptotic cell death. Exposure to an ELF-MF alone (1 mT or 2 mT) did not affect the percentages of G2/M-arrested cells, aneuploid cells, or the populations of cells in the subG1 phase. Moreover, when cells were exposed to a 1 mT or 2 mT ELF-MF in combination with IR (0.5 Gy) or H2O2 (0.05 mM), the ELF-MF did not further increase the percentages of G2/M-arrested cells or aneuploid cells. These results suggest that ELF-MFs alone do not induce either G2/M arrest or aneuploidy, even when administered in combination with different stressors.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Radiación Ionizante / Ciclo Celular / Muerte Celular / Inestabilidad Genómica / Campos Electromagnéticos / Células Epiteliales / Campos Magnéticos / Peróxido de Hidrógeno / Aneuploidia / Pulmón Límite: Humanos Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Radiación Ionizante / Ciclo Celular / Muerte Celular / Inestabilidad Genómica / Campos Electromagnéticos / Células Epiteliales / Campos Magnéticos / Peróxido de Hidrógeno / Aneuploidia / Pulmón Límite: Humanos Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2015 Tipo del documento: Artículo