Roles of Gonadal Steroids on Exocrine Secretion of Isolated Perfused Rat Pancreas
The Korean Journal of Physiology and Pharmacology
; : 217-222, 2003.
Article
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| WPRIM
| ID: wpr-727899
Biblioteca responsable:
WPRO
ABSTRACT
To clarify the roles of gonadal steroids on pancreatic exocrine secretion, effects of progesterone and estradiol-17beta on spontaneous and secretagogue-induced exocrine response of isolated perfused rat pancreas were investigated. Intra-arterial infusion of progesterone resulted in significant increase of the spontaneous pancreatic fluid and amylase secretion dose-dependently. However, estradiol-17beta did not exert any influence on spontaneous pancreatic exocrine secretion. Exogenous secretin, cholecystokinin (CCK), and acetylcholine markedly stimulated pancreatic fluid and amylase secretion. Progesterone initially enhanced secretin-induced amylase secretion, but this stimulatory response declined thereafter to basal value. Moreover, secretin-induced fluid secretion was not affected by infusion of progesterone. Therefore, initial increase of secretion-induced amylase secretion by progesterone seems to be a non-specific action by washout effect of secretin. Estradiol-17beta failed to change the secretin-induced fluid and amylase secretion. Both progesterone and estradiol-17beta did not exert any influence on CCK-induced fluid and amylase secretion. Acetylcholine-induced exocrine secretion of isolated perfused pancreas also was not affected by intra-arterial infusion of progesterone or estradiol-17beta. It is concluded from the above results that progesterone could enhance the spontaneous pancreatic fluid and amylase secretion of isolated perfused rat pancreas through non-genomic short- term action, and that these effects could be masked by more potent stimulants such as secretin, CCK, and acetylcholine.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Páncreas
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Progesterona
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Esteroides
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Colecistoquinina
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Infusiones Intraarteriales
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Secretina
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Acetilcolina
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Estradiol
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Gónadas
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Amilasas
Límite:
Animals
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2003
Tipo del documento:
Article