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Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K⁻ channels in coronary arterial smooth muscle cells
The Korean Journal of Physiology and Pharmacology ; : 415-421, 2017.
Artículo en Inglés | WPRIM | ID: wpr-727974
ABSTRACT
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K⁺ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner. The IC₅₀ value and Hill coefficient for escitalopram-induced inhibition of Kv channels were 9.54±1.33 µM and 0.75±0.10, respectively. Addition of escitalopram did not alter the steady-state activation and inactivation curves, suggesting that the voltage sensors of the channels were not affected. Pretreatment with inhibitors of Kv1.5 and/or Kv2.1 did not affect the inhibitory action of escitalopram on vascular Kv channels. From these results, we concluded that escitalopram decreased the vascular Kv current in a concentration-dependent manner, independent of serotonin reuptake inhibition.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Citalopram / Serotonina / Vasos Coronarios / Miocitos del Músculo Liso / Músculo Liso Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Citalopram / Serotonina / Vasos Coronarios / Miocitos del Músculo Liso / Músculo Liso Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2017 Tipo del documento: Artículo