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Regional difference in spontaneous firing inhibition by GABA(A) and GABA(B) receptors in nigral dopamine neurons
Article en En | WPRIM | ID: wpr-728031
Biblioteca responsable: WPRO
ABSTRACT
GABAergic control over dopamine (DA) neurons in the substantia nigra is crucial for determining firing rates and patterns. Although GABA activates both GABA(A) and GABA(B) receptors distributed throughout the somatodendritic tree, it is currently unclear how regional GABA receptors in the soma and dendritic compartments regulate spontaneous firing. Therefore, the objective of this study was to determine actions of regional GABA receptors on spontaneous firing in acutely dissociated DA neurons from the rat using patch-clamp and local GABA-uncaging techniques. Agonists and antagonists experiments showed that activation of either GABA(A) receptors or GABA(B) receptors in DA neurons is enough to completely abolish spontaneous firing. Local GABA-uncaging along the somatodendritic tree revealed that activation of regional GABA receptors limited within the soma, proximal, or distal dendritic region, can completely suppress spontaneous firing. However, activation of either GABA(A) or GABA(B) receptor equally suppressed spontaneous firing in the soma, whereas GABA(B) receptor inhibited spontaneous firing more strongly than GABA(A) receptor in the proximal and distal dendrites. These regional differences of GABA signals between the soma and dendritic compartments could contribute to our understanding of many diverse and complex actions of GABA in midbrain DA neurons.
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Texto completo: 1 Índice: WPRIM Asunto principal: Árboles / Mesencéfalo / Sustancia Negra / Carisoprodol / Dopamina / Receptores de GABA / Receptores de GABA-A / Dendritas / Neuronas Dopaminérgicas / Incendios Límite: Animals Idioma: En Revista: The Korean Journal of Physiology and Pharmacology Año: 2018 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Árboles / Mesencéfalo / Sustancia Negra / Carisoprodol / Dopamina / Receptores de GABA / Receptores de GABA-A / Dendritas / Neuronas Dopaminérgicas / Incendios Límite: Animals Idioma: En Revista: The Korean Journal of Physiology and Pharmacology Año: 2018 Tipo del documento: Article